Can I take Gabapentin and Modifinil together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking gabapentin and modafinil together may lead to increased side effects such as dizziness, drowsiness, or difficulty concentrating. While modafinil is a stimulant and gabapentin is often used for nerve pain or seizures (and can cause sedation), they do not necessarily 'cancel each other out'. Instead, you might feel a confusing mix of being alert yet dizzy or uncoordinated.
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Why this happens
There is no significant evidence that these drugs change how the other is absorbed or cleared by the body (pharmacokinetics). However, they both affect the central nervous system in opposing ways (pharmacodynamics). This can lead to unpredictable effects on your coordination, alertness, and mental clarity.
What you should do
Back to contentsYou can usually take these together, but you should be cautious, especially when first starting the combination or changing your dose. Do not drive or operate heavy machinery until you know how the mix affects you. If you feel excessively dizzy, confused, or 'spaced out', contact your doctor.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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