Can I take Cordyceps and Lions mane together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There are no known negative interactions between Cordyceps and Lion's Mane mushrooms. In fact, they are frequently taken together in 'mushroom blends' because they work in different ways.
Cordyceps is typically used for energy and physical stamina, while Lion's Mane is used for brain health and focus. Taking them together may provide a combined benefit for both physical and mental performance.
In this article:
It is safe to take cordyceps and Lions mane together. These two supplements do not compete for the same metabolic pathways in the liver, nor do they cancel each other out.
They have 'additive' effects, meaning they work alongside each other without interfering with how the body absorbs or uses them.
Continue reading below
What you should do
When taking cordyceps and Lions mane, you should:
Start with a low dose to see how your body reacts.
Speak to your doctor if you are taking blood-thinning medication or have an upcoming surgery as both mushrooms may have very mild blood-thinning properties.
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Evana heavy period relief and Mefenamic acid together?
Taking these two medicines together significantly increases your risk of serious stomach problems, such as stomach ulcers, bleeding, or irritation of the stomach lining. It can also put extra strain on your kidneys.
Treatment and medication
Can I take Paracetamol and Ibuprofen together?
There is no harmful interaction between paracetamol and ibuprofen. In fact, they are often taken together because they work in different ways to provide better pain relief than either medicine alone.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.