Can I take Flecainide and Rivaroxaban together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no direct interaction between flecainide and rivaroxaban. However, because both drugs are used to treat heart rhythm problems (like atrial fibrillation), they are often prescribed together. Flecainide controls the heart's rhythm, while rivaroxaban prevents blood clots. Taking them together does not change how either drug works in the body.
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Why this happens
Flecainide is primarily processed by a liver enzyme called CYP2D6, while rivaroxaban is processed by different pathways (CYP3A4 and P-gp). Because they use different 'routes' for metabolism and have different targets in the body (one affects electrical signals, the other affects blood clotting), they do not interfere with each other.
What you should do
Back to contentsYou can safely take these two medicines together as prescribed by your doctor. Ensure you attend your regular heart check-ups and blood tests. If you notice any unusual bruising or bleeding (common with rivaroxaban) or feel new heart palpitations (related to the condition flecainide treats), contact your healthcare provider.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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