Can I take Collagen and Tamoxifen together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known direct interaction between collagen supplements and tamoxifen. Collagen is a protein found naturally in the body, and taking it as a supplement is generally considered safe alongside this medication.
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Why this happens
Collagen is broken down into amino acids in the digestive tract, similar to eating protein-rich food. It does not interfere with the liver enzymes (such as CYP2D6) that tamoxifen relies on to work, nor does it have known oestrogen-like effects that would interfere with tamoxifen's purpose.
What you should do
Back to contentsYou can safely take collagen supplements with tamoxifen. However, always choose high-quality supplements from reputable brands to ensure there are no hidden additives or contaminants. If you have any concerns about new supplements, it is always a good idea to mention them to your oncology team.
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Food and drink warnings
Back to contentsGrapefruit and grapefruit juice
Grapefruit contains compounds that can interfere with the enzymes (specifically CYP3A4) that process tamoxifen in your body. This may potentially alter how much of the medicine stays in your bloodstream, although the clinical impact is less severe than with other medications. It is generally advised to avoid large amounts of grapefruit.
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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