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Codeine for pain relief

This medicine is an opioid painkiller. There is a serious risk of addiction when taking this medicine, especially if used long-term. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued new guidance for people prescribed an opioid painkiller. If you have any questions or concerns about taking opioids safely please speak with your doctor or a pharmacist.

Codeine is used to treat mild-to-moderate types of pain.

The most common side effects of codeine are feeling sick (nausea), constipation, feeling sleepy, and dry mouth.

Codeine may affect your reactions. When you first start treatment, do not drive until you know how you react.

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About codeine

Type of medicine

An opioid painkiller (analgesic)

Used for

Pain relief

Also called

Codeine phosphate

Available as

Tablets, oral liquid medicine and injection

Codeine is a type of opioid (a strong painkiller) that is used to treat mild-to-moderate types of pain. It can be particularly useful when painkillers such as paracetamol and ibuprofen have not been effective.

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Codeine works by binding to certain tiny areas, called opioid receptors, in your central nervous system (brain and spinal cord). This leads to a decrease in the way you feel pain and your reaction to pain.

Codeine is available with a prescription from a doctor. It is also included in some pain relief medicines you can buy directly from a pharmacy without a prescription. One example is co-codamol, which contains codeine combined with paracetamol.

Codeine is also combined with the anti-inflammatory medicine ibuprofen in some over-the-counter products.

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Common side effects of codeine include:

  • Feeling sick.

  • Being sick (vomiting).

  • Constipation.

  • Feeling dizzy.

  • Feeling sleepy.

  • Stomach (tummy) pain.

  • Dry mouth.

  • Sweating.

You will find a full list in the manufacturer's information leaflet supplied with your medicine.

The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any side effects continue or become troublesome.

Common codeine side effects

What can I do if I experience this?

Feeling sick or being sick

Stick to simple meals - avoid rich or spicy foods. Also, try taking your doses of codeine after food, as this may help protect your stomach

Constipation

Eat a well-balanced diet and drink plenty of water each day. If this continues to be a problem, speak with your doctor

Feeling dizzy or sleepy

If this happens, do not drive and do not use tools or machines. Do not drink alcohol

Dry mouth, sweating, tummy pain (may be caused by spasm of the bile ducts)

Speak with your doctor if troublesome

Important: people taking opioid medicines, and their family and friends, should be aware of the risk of accidental overdose and know when to seek medical help. The risk is higher if you also take other medicines that make you feel drowsy. Signs you have taken too much medicine include:

  • Feeling very sleepy or dizzy.

  • Feeling sick (nausea) or being sick (vomiting).

  • Breathing difficulties.

  • Loss of consciousness.

If you have taken more codeine than you should or someone else accidentally swallows your medication, call for an ambulance and tell them the name of your medicine.

If you experience other symptoms which you think may be due to codeine, speak with your doctor or pharmacist for further advice.

Some medicines are not suitable for people with certain conditions. Before starting codeine it is important that your doctor knows:

  • If you are pregnant or breastfeeding.

  • If you have a problem with the way your liver works, or a problem with the way your kidneys work.

  • If you have prostate problems or any difficulties passing urine.

  • If you have any breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD).

  • If you have been told you have low blood pressure or an abnormal heart rhythm.

  • If you have any problems with your thyroid or adrenal glands.

  • If you have epilepsy.

  • If you have gallstones or a problem with your bile duct.

  • If you have been constipated for more than a week or have an inflammatory bowel problem.

  • If you have a condition causing muscle weakness, called myasthenia gravis.

  • If you have recently had a severe head injury.

  • If you have ever been dependent on drugs or alcohol.

  • If you have ever had an allergic reaction to a medicine.

  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

  • Read the leaflet inside the pack before you start. It explains how codeine works and lists possible side effects.

  • Take codeine exactly as prescribed by your doctor or pharmacist.

    • The usual dose for pain is 30-60 mg every 4 hours if needed.

  • Do not take it more often than every 4 hours and do not exceed 240 mg in one day.

  • Codeine tablets come in different strengths, always check the label to see how many tablets to take.

  • Swallow the tablets with water. You can take them with or without food, but taking them after food may help prevent feeling sick.

  • If you forget a dose, take it when you remember, then continue as normal. Do not take two doses at the same time to make up for a missed dose.

  • Do not drink alcohol while taking codeine. Alcohol can increase side effects such as dizziness and sleepiness.

  • Codeine can affect your reactions and driving ability. Do not drive until you know how codeine affects you, especially when you first start taking it. The effects of codeine may last into the next day, even if you feel alert.

  • If you are driving while taking codeine, carry proof that it has been prescribed for you (such as the patient leaflet or a prescription slip).

  • Codeine is prescribed for the shortest time needed to reduce the risk of dependence and building a tolerance.

  • Stopping codeine suddenly after taking it for a while can cause withdrawal symptoms, such as feeling restless or irritable.

  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking codeine.

If you buy any medicines, check with a pharmacist that they are safe to take with codeine.

  • Keep all medicines out of the reach and sight of children.

  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

MHRA - Reporting adverse reactions

Report suspected side effects to medicines, vaccines, e-cigarettes, medical device incidents, defective or falsified (fake) products to the Medicines and Healthcare products Regulatory Agency to ensure safe and effective use.

How long does it take for codeine to work?

Codeine usually starts to work within 30 to 60 minutes after taking it, with pain relief typically lasting for around 4 hours. How quickly it works however can vary from person to person.

Is it safe to take codeine during pregnancy?

Codeine can be taken during pregnancy but only for short-term use. It is not recommended during the third trimester as there is a risk that your baby will get used to having codeine and could have withdrawal symptoms.

Can you drink alcohol with codeine?

No, you should not drink alcohol while taking codeine. Alcohol increases the risk of side effects such as drowsiness, dizziness, slowed breathing, and impaired judgement.

Can you take codeine with paracetamol?

Yes, you can take codeine and paracetamol together. They are commonly combined in a medicine called co-codamol. Taking them together can provide better pain relief than either medicine alone.

Is codeine addictive?

Yes, codeine can be addictive if taken regularly or for long periods. Your body can become dependent on it, and stopping suddenly may cause withdrawal symptoms such as restlessness or irritability. For this reason, codeine is usually prescribed for short-term use only.

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Further reading and references

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The information on this page is written and peer reviewed by qualified clinicians.

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