Can I take Oxypro and Pregabalin together?

Why this happens

Both Oxypro (oxycodone) and pregabalin act as depressants on the central nervous system. When taken together, their effects 'stack' or add up. Oxycodone is an opioid painkiller that slows down the brain's control of breathing, and pregabalin enhances this effect, making it much more dangerous than taking either medicine alone.

You must only take these two medicines together if they have been specifically prescribed by the same doctor who is aware you are taking both. Your doctor should start you on the lowest possible doses and monitor you closely.

Seek emergency medical help immediately if you or someone taking these medicines experiences:

• Very slow or shallow breathing

• Extreme sleepiness or inability to stay awake

• Limp muscles or cold, clammy skin

• Pinpoint pupils

• A slow heartbeat or fainting

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.