Can I take Omeprazole and Venlafaxine krka together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking omeprazole and venlafaxine together may increase the amount of venlafaxine in your bloodstream. This could potentially increase the risk of side effects such as nausea, dizziness, dry mouth, or feeling jittery. In rare cases, it might increase the risk of a serious but rare condition called serotonin syndrome.
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Why this happens
Omeprazole can slow down the liver enzymes (specifically CYP2C19) that are responsible for breaking down venlafaxine. Because the body processes the venlafaxine more slowly, the drug can build up to higher levels than intended.
What you should do
Back to contentsYou can usually take these medicines together, but you should be aware of any new or worsening side effects. If you feel unusually agitated, confused, or experience a very fast heartbeat, contact your doctor. Your doctor may choose to adjust your dose of venlafaxine if you need to take omeprazole long-term.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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