Can I take Losartan and Trazodone together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together can cause your blood pressure to drop too low. This might make you feel dizzy, lightheaded, or faint, especially when you stand up quickly from a sitting or lying position.
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Why this happens
Both losartan and trazodone have the effect of lowering blood pressure. Losartan is specifically designed to do this, while trazodone (an antidepressant) can cause low blood pressure as a side effect. When used together, their effects add up.
What you should do
Back to contentsYou should monitor your blood pressure regularly at home. Be careful when getting out of bed or standing up; move slowly to give your body time to adjust. If you feel very dizzy, sit or lie down immediately. Inform your doctor if you experience frequent dizziness or fainting, as they may need to adjust your dosages.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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