Can I take Loratadine and Ibuprofen together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There are no known significant interactions between loratadine and ibuprofen. It is generally considered safe to take these two medicines together.
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Why this happens
Loratadine is an antihistamine used for allergies, and ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain and inflammation. They work in different ways in the body and are processed by different pathways in the liver and kidneys, meaning they do not interfere with each other's effectiveness or safety.
What you should do
Back to contentsYou can take these medicines together if needed. Always follow the dosage instructions on the packaging for each product. If you have underlying health conditions, such as stomach ulcers, kidney problems, or asthma, check with a pharmacist before taking ibuprofen.
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Important precautions
Back to contentsAsthma
Do not take this medicine if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a severe, life-threatening asthma attack.
Stomach ulcers or bleeding
Avoid this medicine if you have a history of stomach ulcers, perforation, or bleeding, as it significantly increases the risk of serious gastrointestinal damage.
Pregnancy (third trimester)
Do not take ibuprofen if you are more than 28 weeks pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking ibuprofen can increase the risk of stomach irritation and serious side effects like stomach bleeding or ulcers. It is best to limit or avoid alcohol while taking this medicine.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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