Can I take Ibuprofen and Amoxicillin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known harmful interaction between ibuprofen and amoxicillin. It is generally safe to take these two medicines together.
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Why this happens
Amoxicillin is an antibiotic that kills bacteria, while ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation. They work in different ways and are processed by the body through different pathways, so they do not interfere with each other's effectiveness or safety.
What you should do
Back to contentsYou can take both medicines as prescribed by your doctor or pharmacist. To help prevent stomach upset, it is a good idea to take ibuprofen with food or a milky drink. Always finish the full course of amoxicillin, even if you start to feel better.
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Important precautions
Back to contentsAsthma
Do not take this medicine if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.
Stomach ulcers or bleeding
Avoid this medicine if you have ever had a stomach ulcer or gastrointestinal bleeding, as it can cause serious internal bleeding or perforation.
Penicillin allergy
Do not take this medicine if you have ever had an allergic reaction to penicillin or cephalosporin antibiotics, as it can cause a severe, life-threatening reaction (anaphylaxis).
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking ibuprofen can increase the risk of stomach irritation and bleeding. It is best to limit or avoid alcohol, especially if you are taking ibuprofen long-term.
Food (General)
It is recommended to take ibuprofen with food or a glass of milk to reduce the risk of stomach upset or indigestion.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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