Can I take Glucosamine and Oestrogel pump-pack /actuation together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known interaction between glucosamine and Oestrogel (estradiol). It is generally considered safe to use these two products together.
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Why this happens
Glucosamine is a supplement used for joint health, while Oestrogel is a hormone replacement therapy (HRT) applied to the skin. They are processed by the body through different pathways and do not interfere with how the other is absorbed, used, or cleared from the system.
What you should do
Back to contentsYou can continue to use both products as directed. As with any supplement, if you notice any unusual symptoms or if you have underlying conditions like diabetes or are taking blood-thinning medication (like warfarin), you should mention your glucosamine use to your doctor or pharmacist.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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