Can I take Evolocumab and Ezetimibe together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking evolocumab and ezetimibe together is a common and safe combination. Both medicines work to lower your 'bad' cholesterol (LDL), and using them together helps lower it more effectively than using either one alone. There is no evidence that they interfere with each other in a harmful way.
In this article:
Continue reading below
Why this happens
These drugs work in different ways to achieve the same goal. Ezetimibe reduces the amount of cholesterol your body absorbs from food, while evolocumab (a PCSK9 inhibitor) helps your liver clear more cholesterol out of your blood. Because they use different pathways, they have an 'additive' effect, meaning they work together to improve your results without changing how the other drug is processed by the body.
What you should do
Back to contentsYou can safely take these two medicines together as prescribed by your doctor. Ensure you continue to follow any dietary advice provided by your healthcare team and attend your regular blood tests to monitor your cholesterol levels.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Co-codamol and Ibuprofen together?
It is safe to take co-codamol and ibuprofen together. They are different types of painkillers that work in different ways to provide better pain relief than taking either one alone.

Treatment and medication
Can I take Magnesium and Sertraline together?
There is no known direct interaction between magnesium supplements and sertraline. It is generally considered safe to take them together.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.