Can I take Esomeprazole and Tizanidine together?

Why this happens

Tizanidine is broken down in the body by a specific liver enzyme (CYP1A2). Esomeprazole interferes with this enzyme, slowing down how quickly the body can get rid of tizanidine. This causes the medicine to build up to potentially dangerous levels.

You should speak to your doctor before taking these two medicines together. They may want to adjust your dose of tizanidine or suggest an alternative acid-reducing medication (such as famotidine) that does not interfere with your liver enzymes in the same way. If you are already taking both and feel unusually sleepy or faint, seek medical advice immediately.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.