Can I take Esomeprazole and Ezetimibe together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There are no known significant interactions between esomeprazole and ezetimibe. It is generally considered safe to take these two medications together.
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Why this happens
Esomeprazole (a proton pump inhibitor) and ezetimibe (a cholesterol absorption inhibitor) work through different pathways in the body and do not significantly interfere with each other's absorption, metabolism, or excretion.
What you should do
Back to contentsYou can continue to take both medications as prescribed by your doctor. No special precautions or timing adjustments are necessary for this specific combination.
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Important precautions
Back to contentsMuscle problems (Myopathy/Rhabdomyolysis)
Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness. The risk is higher if taken with a statin.
Severe diarrhoea (C. difficile)
Seek medical help if you develop severe or persistent watery diarrhoea, as this medicine can increase the risk of a serious bowel infection.
Vitamin B12 deficiency and bone fractures
Long-term use (over a year) can weaken bones and lead to low magnesium or B12 levels; your doctor should monitor these if you are on long-term treatment.
Food and drink warnings
Back to contentsAlcohol
While alcohol does not directly interact with esomeprazole, it can increase stomach acid production and irritate the stomach lining, which may worsen the symptoms your medicine is intended to treat. It is best to limit alcohol intake.
Caffeine
Caffeine (found in coffee, tea, and some fizzy drinks) can trigger or worsen acid reflux and heartburn. This may make esomeprazole less effective at managing your symptoms.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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