Can I take Co-codamol and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking co-codamol and sertraline together can increase the risk of a rare but serious condition called serotonin syndrome. It can also make you feel more drowsy, dizzy, or confused than usual. Additionally, sertraline may stop the codeine in co-codamol from working properly, meaning you might not get the pain relief you expect.
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Why this happens
Both drugs affect a chemical in the brain called serotonin; when levels get too high, it causes side effects. Furthermore, sertraline blocks a specific liver enzyme (CYP2D6) that the body needs to convert codeine into morphine. If this conversion doesn't happen, the pain-killing effect is lost.
What you should do
Back to contentsSpeak to your doctor before combining these medicines. If you must take both, be alert for signs of serotonin syndrome, such as shivering, diarrhoea, fever, sweating, or muscle stiffness. If you find that co-codamol is not helping your pain, your doctor may suggest an alternative painkiller like paracetamol (without codeine) or ibuprofen.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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