Can I take Cannabis and Ibuprofen together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Using cannabis and ibuprofen together may increase the risk of side effects such as stomach irritation, indigestion, or a higher risk of bleeding. It may also increase the chance of feeling dizzy, drowsy, or confused.
In this article:
Continue reading below
Why this happens
Both substances can affect the lining of the stomach and how blood clots (pharmacodynamic effect). Additionally, cannabis may slow down the liver's ability to process certain non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, potentially leading to higher levels of the medicine in your system (pharmacokinetic effect).
What you should do
Back to contentsUse caution when combining these two. If you need to take them together, use the lowest dose of ibuprofen possible for the shortest time. Watch for signs of stomach pain, dark stools, or unusual bruising. If you feel excessively dizzy or sleepy, avoid driving or operating machinery.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Amlopadine and Atorvastatin together?
Taking amlodipine and atorvastatin together can increase the amount of atorvastatin in your blood. This may increase the risk of side effects, particularly muscle pain, tenderness, or weakness (a condition called myopathy). In rare cases, this can lead to a more serious muscle breakdown called rhabdomyolysis.

Treatment and medication
Can I take Bactrim and Venlafaxine dexcel together?
Taking these two medicines together can increase the risk of a rare but serious condition called serotonin syndrome. It can also lead to an imbalance of salts in your blood (low sodium) and, in some cases, may affect your heart rhythm.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.