Can I take Atorvastatin and Colecalciferol together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking atorvastatin and colecalciferol (Vitamin D3) together is generally safe and may even be beneficial. Some studies suggest that Vitamin D can slightly lower the levels of atorvastatin in your blood, but this rarely affects how well the medicine works to lower your cholesterol. Conversely, atorvastatin may actually help increase your Vitamin D levels.
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Why this happens
Both substances are processed by the same enzyme in the liver (CYP3A4). Because they compete for this enzyme, they can slightly influence each other's levels, but not to a degree that is clinically dangerous for most people.
What you should do
Back to contentsYou can continue taking both medications as prescribed. You do not need to change the timing of your doses. If you experience any unusual muscle pain or weakness (a rare side effect of statins), you should always inform your doctor, regardless of whether you are taking Vitamin D.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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