Can I take Aspirin 300 and Naproxen together?

Why this happens

Both drugs belong to the same family (NSAIDs) and work by blocking enzymes called COX-1 and COX-2. When used together, they have an 'additive' effect on the stomach lining, making it much more vulnerable to damage. Furthermore, naproxen can physically block the spot where aspirin needs to attach to your blood cells (platelets), preventing aspirin from thinning the blood properly.

You should not take these two medicines together unless specifically instructed and monitored by your doctor. If you require pain relief while taking aspirin, paracetamol is generally a safer alternative. If your doctor has prescribed both, watch for signs of stomach bleeding, such as black tarry stools, coughing up blood, or severe stomach pain.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.