Can I take Amytriptaline and Aspirin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking amitriptyline and aspirin together can increase your risk of bleeding, particularly in the stomach or gut. You may also find that you bruise more easily.
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Why this happens
Amitriptyline belongs to a group of medicines that can affect how your blood platelets work. Aspirin is a blood-thinner that also stops platelets from sticking together. When used together, their combined effect makes it harder for your blood to clot, increasing the risk of internal bleeding.
What you should do
Back to contentsUse this combination with caution. If you need to take them together, watch for signs of bleeding such as dark, tarry stools, coughing up blood, or severe stomach pain. If you notice these symptoms, contact your doctor immediately. Your doctor may suggest a different painkiller or a medicine to protect your stomach.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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