Can I take Amlodipine and Paracetamol together?

Why this happens

Amlodipine and paracetamol are processed by different pathways in the body and do not interfere with how the other works. Amlodipine works by relaxing blood vessels to lower blood pressure, while paracetamol works on the central nervous system to reduce pain and fever.

You can take these medicines together as prescribed. Always follow the dosage instructions on the packaging or as advised by your doctor or pharmacist.

Liver disease or heavy alcohol consumption

Paracetamol is processed by the liver. If you have liver problems or drink large amounts of alcohol, you are at a much higher risk of fatal liver damage even at standard doses. Never exceed the maximum dose of 8 tablets (4g) in 24 hours.

Severe heart disease (Aortic Stenosis)

Amlodipine can cause a dangerous drop in blood pressure if you have severe narrowing of the aortic heart valve (aortic stenosis), which may lead to fainting or heart failure.

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood. This may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swollen ankles. While a small glass is unlikely to cause problems for most people, it is best to avoid large amounts of grapefruit juice while taking this medicine.

Alcohol

You can usually drink alcohol in moderation while taking these medicines. However, for amlodipine, alcohol can increase the blood-pressure lowering effect, which might make you feel dizzy or lightheaded. For paracetamol, chronic heavy drinking increases the risk of liver damage.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.