Can I take Amitriptyline and Tizanidine together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking amitriptyline and tizanidine together can make you feel extremely drowsy, dizzy, and lightheaded. It can also cause a significant drop in blood pressure, which might lead to fainting. You may find it very difficult to concentrate or perform tasks that require alertness.
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Why this happens
Both drugs have a 'depressing' effect on the central nervous system (brain and nerves). When used together, these effects are added together (additive effect). Additionally, both medications can lower blood pressure and slow down your heart rate.
What you should do
Back to contentsYou should speak to your doctor before taking these two medicines together. If your doctor prescribes both, they may start you on a lower dose and monitor you closely. Do not drive or operate machinery until you know how this combination affects you. Seek medical help immediately if you feel very faint, confused, or have a very slow heartbeat.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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