Can I take Amitriptyline and Esomeprazole together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking esomeprazole alongside amitriptyline may increase the levels of amitriptyline in your bloodstream. This could make you more likely to experience side effects such as extreme sleepiness, a dry mouth, blurred vision, constipation, or a fast heartbeat.
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Why this happens
Amitriptyline is broken down in the liver by specific proteins (enzymes). Esomeprazole can slow down the activity of these proteins, which means the amitriptyline stays in your system longer and reaches higher levels than intended.
What you should do
Back to contentsYou can take these medicines together, but you should be aware of the potential for increased side effects. If you feel unusually drowsy, dizzy, or notice your heart racing, speak to your doctor. They may decide to adjust your dose of amitriptyline.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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